Clomid (Clomiphene) for Infertility: What You Need to Know

by Jenny Argiriou, last updated 12 Aug 2024,

3 min read

Infertility can be a challenging journey, but there are effective treatments available that can help you achieve your dream of starting a family. One of the most commonly prescribed medications for infertility is Clomid, also known by its generic name, clomiphene citrate. Here’s everything you need to know about Clomid and how it can help boost your chances of conception.

What is Clomid?

Clomid is an oral medication that has been used since the 1960s to treat infertility in women. It is particularly effective for women who have trouble ovulating on their own, a condition known as anovulation. Clomid is often the first line of treatment recommended by doctors due to its long history of success and relatively low cost.

How Does Clomid Work?

Clomid works by tricking your brain into thinking that your estrogen levels are lower than they actually are. It does this by binding to estrogen receptors in the brain, which blocks the actual estrogen from binding. This causes the brain to release more gonadotropin-releasing hormone (GnRH), which in turn stimulates the pituitary gland to produce more follicle-stimulating hormone (FSH) and luteinizing hormone (LH). These hormones are crucial for the development and release of mature eggs from the ovaries.

Who Can Benefit from Clomid?

Clomid is particularly beneficial for:

  • Women with polycystic ovarian syndrome (PCOS), a common cause of anovulation.
  • Women with irregular menstrual cycles.
  • Women with unexplained infertility.
  • Couples undergoing intrauterine insemination (IUI) to increase the chances of conception.

How is Clomid Taken?

Clomid is typically taken in pill form for five days, usually starting on the third, fourth, or fifth day of your menstrual cycle. The initial dose is often 50 mg per day, but your doctor may adjust the dosage based on your response. Monitoring through blood tests and ultrasounds is often recommended to track your body’s response and to time intercourse or IUI accurately.

Success Rates and What to Expect

The success rates with Clomid are promising:

  • Approximately 80% of women will ovulate while taking Clomid.
  • Of those who ovulate, about 10-15% will conceive per cycle.
  • The chances of conceiving multiples (twins or more) are higher with Clomid, with about 7% of pregnancies resulting in twins.



Side Effects and Risks

Like any medication, Clomid comes with potential side effects, although they are generally mild. Common side effects include:

  • Hot flashes
  • Bloating
  • Nausea
  • Breast tenderness
  • Mood swings
    More severe side effects are rare but can include ovarian hyperstimulation syndrome (OHSS), which can cause significant abdominal pain and bloating. It’s crucial to be under the care of a healthcare provider who can monitor your response to the medication.

When to Seek Further Treatment

If you do not conceive after three to six cycles of Clomid, it may be time to explore other fertility treatments. Your doctor might suggest moving on to injectable hormones or assisted reproductive technologies like in vitro fertilization (IVF).

Final Thoughts

Clomid has helped countless women achieve their dream of becoming mothers. Its long history of use, combined with its effectiveness and relatively low cost, makes it a popular choice for treating infertility. If you’re struggling with ovulation issues or have been diagnosed with PCOS, Clomid might be the right option for you. Always consult with your healthcare provider to determine the best treatment plan tailored to your needs.

For more personalized advice and to explore your fertility treatment options, don’t hesitate to contact our team of experts. By understanding how Clomid works and what to expect, you can take an informed step towards achieving your dream of parenthood. Remember, you’re not alone on this journey, and there are many resources and treatments available to support you.

Jenny Argiriou

Jenny Argiriou, BSc

Jenny is a Biologist and International Patient Coordinator at Newlife IVF Greece.

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