What to Expect from Beta-hCG Levels After an IVF Cycle?

In vitro fertilization (IVF) is a process that brings hope to many couples trying to start a family. One of the most critical stages after an embryo transfer is measuring the levels of beta-human chorionic gonadotropin (β-hCG), a hormone that indicates successful implantation and pregnancy.

What is Beta-hCG?

Beta-hCG (human chorionic gonadotropin) is a hormone produced by the trophoblastic cells surrounding the developing embryo and later by the placenta after the implantation of the embryo in the uterus. Its presence in a woman's blood or urine is an indication of pregnancy. The levels of beta-hCG rise rapidly during the first weeks of pregnancy and nearly double every 48-72 hours.

When is Beta-hCG Measured After IVF?

The first measurement of beta-hCG is usually scheduled 14 days after egg retrieval in a fresh cycle (embryo transfer on the fifth day of its development) or 9 days after the transfer of a cryopreserved embryo (blastocyst). This is done to avoid false-positive results that may be caused by the preceding medication.

Expected Beta-hCG Levels

Beta-hCG levels can vary significantly between women and pregnancies. However, there are general guidelines:

• 9th Day Post-Embryo Transfer: Levels may range from 50 to 100 mIU/ml. Lower levels might indicate implantation failure or biochemical pregnancy, while higher levels could suggest a multiple pregnancy.
• 14th Day Post-Egg Retrieval: Levels are expected to be higher and continue rising. Doubling of β-hCG levels every 48-72 hours is a positive sign of pregnancy progression.

What do Beta-hCG Levels Indicate?

Low Levels: May suggest implantation failure or a biochemical pregnancy.
High Levels: Could indicate a multiple pregnancy or, in rare cases, a molar pregnancy.
Stable or Decreasing Levels: Might indicate a miscarriage or a biochemical pregnancy.

Conclusion

The measurement of beta-hCG is a critical step after in vitro fertilization, as it provides the first indications of the success of the procedure. It is important to monitor the beta-hCG levels and communicate with your doctor to better understand the results and the next steps. In the field of in vitro fertilization, and more generally for couples facing infertility issues, the quantitative measurement of beta-hCG through a blood test is crucial for the correct interpretation of the treatment outcome.

If you have any questions, don't hesitate to contact our team. We are here to support you every step of the way on this journey.